Gluconeogenesis from Serine by the Serine-Dehydratase-Dependent Pathway in Rat Liver
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چکیده
منابع مشابه
The separation of rat liver serine dehydratase and cystathionine synthase.
A compound derived from pyruvic acid and homocysteine has been isolated from reaction mixtures containing serinel*C, homocysteine, and serine dehydratase preparations. The formation of this product interferes with commonly used assays of serine dehydratase, which are based on the serine, pyruvic acid, or homocysteine content of incubation mixtures. Improved assay procedures have permitted the i...
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Although it is assumed that amino acids constitute the main source of glucose production in animals, relatively little modern work has been done on the magnitude of gluconeogenesis from amino acids or on the factors which might influence this process. Studies conducted in early years were based principally on the experimental techniques of measuring glucose excretion in phlorizinized or depancr...
متن کاملA novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae.
YGL196W of Saccharomyces cerevisiae encodes a putative protein that is unidentified but is predicted to have a motif similar to that of the N-terminal domain of the bacterial alanine racemase. In the present study we found that YGL196W encodes a novel D-serine dehydratase, which belongs to a different protein family from that of the known bacterial enzyme. The yeast D-serine dehydratase purifie...
متن کاملCrystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver.
L-serine dehydratase (SDH), a member of the beta-family of pyridoxal phosphate-dependent (PLP) enzymes, catalyzes the deamination of L-serine and L-threonine to yield pyruvate or 2-oxobutyrate. The crystal structure of L-serine dehydratase from human liver (hSDH) has been solved at 2.5 A-resolution by molecular replacement. The structure is a homodimer and reveals a fold typical for beta-family...
متن کاملRegulation of hepatic L-serine dehydratase and L-serine-pyruvate aminotransferase in the developing neonatal rat.
1. The activities of l-serine dehydratase and l-serine-pyruvate aminotransferase were determined in rat liver during foetal and neonatal development. 2. l-Serine-pyruvate aminotransferase activity begins to develop in late-foetal liver, increases rapidly at birth to a peak during suckling and then decreases at weaning to the adult value. 3. l-Serine dehydratase activity is very low prenatally, ...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1974
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1974.tb03448.x